HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus.

doi:10.1038/329599a0

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Article

HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus.

Nature - 1 Jan 2000

Todd J A, Bell J I, McDevitt H O

Abstract excerpt

Over half of the inherited predisposition to insulin-dependent diabetes mellitus maps to the region of chromosome 6 that contains the highly polymorphic HLA class II genes which determine immune responsiveness. Analysis of DNA sequences from diabetics indicates that alleles of HLA-DQ beta determi...

Topics

Alleles
Amino Acid Sequence
Base Sequence
Chromosomes, Human, Pair 6
Diabetes Mellitus, Type 1
Disease Susceptibility
Genetic Linkage
HLA-D Antigens
HLA-DQ Antigens
HLA-DR Antigens
Haploidy
Histocompatibility Antigens Class II
Humans
Immunity, Innate
Islets of Langerhans
Molecular Sequence Data
Oligonucleotides
Polymorphism, Genetic

Source

Open in PubMed

Identifiers

PMID: 3309680
DOI: 10.1038/329599a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-3309680-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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