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Article

HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus.

Nature - 1 Jan 2000

Todd J A, Bell J I, McDevitt H O

Abstract excerpt

Over half of the inherited predisposition to insulin-dependent diabetes mellitus maps to the region of chromosome 6 that contains the highly polymorphic HLA class II genes which determine immune responsiveness. Analysis of DNA sequences from diabetics indicates that alleles of HLA-DQ beta determine both disease susceptibility and resistance, and that the structure of the DQ molecule, in particular residue 57 of...

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Source

Identifiers

PMID: 3309680
DOI: 10.1038/329599a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus.PMID 3309680Read ↗

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HLA-DQA and DQB alleles contribute to susceptibility to insulin-dependent diabetes mellitus.Semantic proximity Read ↗

A new model defines the minimal set of polymorphism in HLA-DQ and -DR that determines susceptibility and resistance to autoimmune diabetes.Semantic proximity Read ↗

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Particular HLA-DQ molecules play a dominant role in determining susceptibility or resistance to type 1 (insulin-dependent) diabetes mellitus.Semantic proximity Read ↗

Analysis of HLA-DQ genotypes and susceptibility in insulin-dependent diabetes mellitus.Semantic proximity Read ↗

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