Article
Implication of specific DQB1 alleles in genetic susceptibility and resistance by identification of IDDM siblings with novel HLA-DQB1 allele and unusual DR2 and DR1 haplotypes.
Diabetes - 1 Apr 1991
Erlich H A, Griffith R L, Bugawan T L, Ziegler R, Alper C, Eisenbarth G
Abstract excerpt
Genetic susceptibility to insulin-dependent diabetes mellitus (IDDM) is associated with the HLA-DR3 and DR4 haplotypes. The HLA-DR2 haplotype is negatively associated with IDDM, an association that has been interpreted as dominant protection. Here, we describe the molecular analysis of the HLA class II genes in an unusual family with three HLA-DR1/2 siblings, all of whom have IDDM. With polymerase chain reaction...
Topics
- Adolescent
- Adult
- Alleles
- Amino Acid Sequence
- Child
- Codon
- Diabetes Mellitus, Type 1
- Exons
- Female
- Genetic Predisposition to Disease
- HLA-DQ Antigens