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Article

Increased alternative lengthening of telomere phenotypes of telomerase-negative immortal cells upon trichostatin--a treatment.

Anticancer research - 1 Mar 2013

Jung A Ra, Yoo Jeong Eun, Shim Yhong-Hee, Choi Ye-Na, Jeung Hei-Cheul, Chung Hyun Cheol, Rha Sun Young, Oh Bong-Kyeong

Abstract excerpt

Human immortal cells maintain their telomeres either by telomerase or by alternative lengthening of telomeres (ALT) that is based on homologous telomeric recombination. Previous studies showed that the ALT mechanism is activated in non-ALT cells when heterochromatic features are reduced. In this study, we examined the ALT phenotypes of ALT cells after treatment with trichostatin-A (TSA), which is an inhibitor of...

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PMID: 23482750

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PML

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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