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Article

Loss of Wild-Type ATRX Expression in Somatic Cell Hybrids Segregates with Activation of Alternative Lengthening of Telomeres

20 Nov 2012

Abstract excerpt

Alternative Lengthening of Telomeres (ALT) is a non-telomerase mechanism of telomere lengthening that occurs in about 10% of cancers overall and is particularly common in astrocytic brain tumors and specific types of sarcomas. Somatic cell hybridization analyses have previously shown that normal telomerase-negative fibroblasts and telomerase-positive immortalized cell lines contain repressors of ALT activity,...

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PMID: 23185534
DOI: 10.1371/journal.pone.0050062

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Loss of Wild-Type ATRX Expression in Somatic Cell Hybrids Segregates with Activation of Alternative Lengthening of TelomeresPMID 23185534Read ↗

Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres PathwaySemantic proximity Read ↗

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The Role of ATRX in the Alternative Lengthening of Telomeres (ALT) PhenotypeSemantic proximity Read ↗

A non-genetic switch triggers alternative telomere lengthening and cellular immortalization in ATRX deficient cellsSemantic proximity Read ↗

Rapid and reversible suppression of ALT by DAXX in osteosarcoma cellsSemantic proximity Read ↗

Alternative mechanisms of telomere lengthening: permissive mutations, DNA repair proteins and tumorigenic progression.Semantic proximity Read ↗

The alternative lengthening of telomere phenotype is significantly associated with loss of ATRX expression in high-grade pediatric and adult astrocytomas: a multi-institutional study of 214 astrocytomas.Semantic proximity Read ↗

Cancer-Associated DAXX Mutations Reveal a Critical Role for ATRX Localization in ALT Suppression.Semantic proximity Read ↗

Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitorsSemantic proximity Read ↗

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