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Attenuated DNA Damage Repair by Trichostatin A through BRCA1 Suppression

19 Jun 2007

Abstract excerpt

Recent studies have demonstrated that some histone deacetylase (HDAC) inhibitors enhance cellular radiation sensitivity. However, the underlying mechanism for such a radiosensitizing effect remains unexplored. Here we show evidence that treatment with the HDAC inhibitor trichostatin A (TSA) impairs radiation-induced repair of DNA damage. The effect of TSA on the kinetics of DNA damage repair was measured by...

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PMID: 17722998
DOI: 10.1667/rr0811.1

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Attenuated DNA Damage Repair by Trichostatin A through BRCA1 SuppressionPMID 17722998Read ↗

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