Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Histone Deacetylation Is Involved in the Transcriptional Repression of hTERT in Normal Human Cells

1 Nov 2000

Abstract excerpt

Trancriptional regulation of the human telomerase reverse transcriptase (hTERT) gene, encoding the catalytic protein of human telomerase, plays a critical role in the activation of the enzyme during cell immortalization and tumorigenesis. However, the molecular mechanisms involved in the regulation of hTERT expression are still not fully understood. We have previously cloned and characterized the genomic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Microplastics and Plastic Pollution
Share to RNA Interference and Gene Delivery
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10986277
DOI: 10.1074/jbc.c000637200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Histone Deacetylation Is Involved in the Transcriptional Repression of hTERT in Normal Human CellsPMID 10986277Read ↗

The Histone Deacetylase Inhibitor Trichostatin A Derepresses the Telomerase Reverse Transcriptase (hTERT) Gene in Human CellsSemantic proximity Read ↗

Evidence for a Relief of Repression Mechanism for Activation of the Human Telomerase Reverse Transcriptase PromoterSemantic proximity Read ↗

Telomerase activation by histone deacetylase inhibitor in normal cellsSemantic proximity Read ↗

Identification of Mad as a repressor of the human telomerase (hTERT) geneSemantic proximity Read ↗

Telomerase Promoter Reprogramming and Interaction with General Transcription Factors in the Human Mesenchymal Stem CellSemantic proximity Read ↗

Acetylation of PML is involved in histone deacetylase inhibitor-mediated apoptosis.Semantic proximity Read ↗

Histone deacetylase 3 represses HTLV-1 tax transcription.Semantic proximity Read ↗

Sp1 and Sp3 recruit histone deacetylase to repress transcription of human telomerase reverse transcriptase (hTERT) promoter in normal human somatic cells.Semantic proximity Read ↗

Increased alternative lengthening of telomere phenotypes of telomerase-negative immortal cells upon trichostatin--a treatment.Semantic proximity Read ↗

Histone Deacetylation of RB-Responsive Promoters: Requisite for Specific Gene Repression but Dispensable for Cell Cycle InhibitionSemantic proximity Read ↗

The hTERT Gene Is Embedded in a Nuclease-resistant Chromatin DomainSemantic proximity Read ↗

Chromatin remodeling: recruitment of histone demethylase RBP2 by Madl for transcriptional repression of a Myc target gene, telomerase reverse transcriptaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.