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Article

Alternative Lengthening of Telomeres is characterized by reduced compaction of telomeric chromatin

5 Feb 2014

Abstract excerpt

Proper telomeric chromatin configuration is thought to be essential for telomere homeostasis and stability. Previous studies in mouse suggested that loss of heterochromatin marks at telomeres might favor onset of Alternative Lengthening of Telomeres (ALT) pathway, by promoting homologous recombination. However, analysis of chromatin status at human ALT telomeres has never been reported. Here, using isogenic human...

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PMID: 24500201
DOI: 10.1093/nar/gku114

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