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Article

The alternative lengthening of telomeres pathway may operate in non‐neoplastic human cells

12 Aug 2011

Abstract excerpt

The alternative lengthening of telomeres (ALT) mechanism represents an alternative to the enzyme telomerase in the maintenance of mammalian telomeres in 25-60% of sarcomas and a minority of carcinomas (about 5-15%). ALT-positive cells are distinguished by long and heterogeneous telomere length distributions by terminal restriction fragment (TRF) Southern blotting. Another diagnostic marker of ALT is discrete...

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Share to DNA Repair Mechanisms
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PMID: 22250043
DOI: 10.1002/path.2981

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