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Article

Evidence for a Relief of Repression Mechanism for Activation of the Human Telomerase Reverse Transcriptase Promoter

1 May 2003

Abstract excerpt

The transcriptional activation of human telomerase reverse transcriptase (hTERT) is an important step during cellular immortalization and tumorigenesis. To study how this activation occurs during immortalization, we have established a set of genetically related pre-crisis cells and their immortal progeny. As expected, hTERT mRNA was detected in our telomerase-positive immortal cells but not in pre-crisis cells or...

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Share to Chromosomal and Genetic Variations
Share to DNA Repair Mechanisms
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 12611896
DOI: 10.1074/jbc.m209544200

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Related research

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Research trail→

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Evidence for a Relief of Repression Mechanism for Activation of the Human Telomerase Reverse Transcriptase PromoterPMID 12611896Read ↗

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Transcription Regulation of the Human Telomerase Reverse Transcriptase (hTERT) GeneSemantic proximity Read ↗

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