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Article

Alternative Lengthening of Telomeres Is Characterized by High Rates of Telomeric Exchange

1 Apr 2004

Abstract excerpt

Telomere maintenance activity is a hallmark of cancer. In some telomerase-negative tumors, telomeres become lengthened by alternative lengthening of telomeres (ALT), a recombination-mediated DNA replication process in which telomeres use other telomeric DNA as a copy template. Using chromosome orientation fluorescence in situ hybridization, we found that postreplicative exchange events involving a telomere and...

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Share to Chromosomal and Genetic Variations
Share to DNA Repair Mechanisms
Share to Telomeres, Telomerase, and Senescence

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PMID: 15059879
DOI: 10.1158/0008-5472.can-03-4035

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