Article
The PTPN22 1858T allele but not variants in the proximal promoter region of IL-21 gene is associated with the susceptibility to type 1 diabetes and the presence of autoantibodies in a Brazilian cohort.
Clinical and experimental immunology - 1 Apr 2013
Mainardi-Novo D T O, Santos A S, Fukui R T, Gamberini M, Correia M R S, Ruiz M O, Mangueira C L P, Matioli S R, Vasconcelos D M, Silva M E R
Abstract excerpt
Interleukin (IL)-21 and protein tyrosine phosphatase non-receptor 22 (PTPN22) regulate lymphocyte function and have been implicated in the pathogenesis of autoimmune diabetes. We sequenced the proximal promoter of the IL-21 gene for the first time and analysed the PTPN22 1858T polymorphism in type 1A diabetes (T1AD) patients and healthy controls (HC). We correlated the frequencies of islet and extra-pancreatic...
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