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Article

Association between PTPN22 C1858T and type 1 diabetes: a replication in continental Italy.

Tissue antigens - 1 Mar 2008

Saccucci P, Del Duca E, Rapini N, Verrotti A, Piccinini S, Maccari A, Canu G, Angelini F, Fontana L, Giannini C, Chiarelli F, Manca Bitti M L, Bottini N

Abstract excerpt

The missense PTPN22 C1858T polymorphism recently emerged as an important population-independent risk factor for type 1 diabetes (T1D) and other autoimmune diseases. The PTPN22 gene encodes the lymphoid tyrosine phosphatase (LYP), a negative regulator of signal transduction through the T-cell receptor. Although the frequency of the polymorphism is variable among different ethnic groups, the association between...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18179648
DOI: 10.1111/j.1399-0039.2007.00987.x

Genes

PTPN22

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Association between PTPN22 C1858T and type 1 diabetes: a replication in continental Italy.PMID 18179648Read ↗

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The putative role of the C1858T polymorphism of protein tyrosine phosphatase PTPN22 gene in autoimmunity.Semantic proximity Read ↗

PTPN22 gene polymorphism (C1858T) is associated with susceptibility to type 1 diabetes: a meta-analysis of 19,495 cases and 25,341 controls.Semantic proximity Read ↗

Population-based and family-based studies on the protein tyrosine phosphatase non-receptor 22 gene polymorphism and type 1 diabetes: a meta-analysis.Semantic proximity Read ↗

PTPN22 R620W functional variant in type 1 diabetes and autoimmunity related traits.Semantic proximity Read ↗

Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus.Semantic proximity Read ↗

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Association of PTPN22 C1858T polymorphism and type 1 diabetes: a meta-analysis.Semantic proximity Read ↗

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