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Article

The protein tyrosine phosphatase non-receptor type 22 C1858T polymorphism is a joint susceptibility locus for immunthyroiditis and autoimmune diabetes.

Thyroid : official journal of the American Thyroid Association - 1 Feb 2009

Dultz Georg, Matheis Nina, Dittmar Manuela, Röhrig Bernd, Bender Klaus, Kahaly George J

Abstract excerpt

BACKGROUND: The lymphoid tyrosine phosphatase (LYP) encoded by the protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene is a strong inhibitor of T cells. The single nucleotide polymorphism (SNP) C1858T within the PTPN22 gene was recently associated with autoimmune thyroid disease (AITD) and type I diabetes (T1D). The purpose of this study was to examine the joint association of this polymorphism with...

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Amino Acid Sequence
Autoantibodies
Child
Diabetes Mellitus, Type 1
Point Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Tyrosine Phosphatase, Non-Receptor Type 22

Thyroiditis, Autoimmune

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Identifiers

PMID: 19090780
DOI: 10.1089/thy.2008.0301

Genes

PTPN22

Variants

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The protein tyrosine phosphatase non-receptor type 22 C1858T polymorphism is a joint susceptibility locus for immunthyroiditis and autoimmune diabetes.PMID 19090780Read ↗

Association of Protein Tyrosine Phosphatase Nonreceptor 22 (PTPN22) C1858T gene polymorphism with susceptibility to autoimmune thyroid diseases: a meta-analysis.Semantic proximity Read ↗

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C1858T Polymorphism of Protein Tyrosine Phosphatase Non-receptor Type 22 (PTPN22): an eligible target for prevention of type 1 diabetes?Semantic proximity Read ↗

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