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Article

Non-HLA risk variants in a type 1 diabetes pediatric population: Clinical and autoimmune profiles.

Anales de pediatria - 1 Jan 2026

Díez Blanco Miriam, Pérez Barrios Clara, Donoso Navarro María Encarnación, Santiesteban Rodríguez Nuria, Martínez-Badás Itziar, Colino Alcol Esmeralda, Ros Pérez Purificación

Abstract excerpt

INTRODUCTION: The interplay between genetic and environmental factors plays a critical role in the development of type 1 diabetes (T1D). While variants in non-HLA coding regions have been identified as potential therapeutic targets, their exact contribution to the pathophysiology of disease remains unclear. The aim of the study was to characterize six non-HLA variants in pediatric patients with T1D and explore...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Diabetes Mellitus, Type 1

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Share to Protein Tyrosine Phosphatase, Non-Receptor Type 22

Source

Identifiers

PMID: 41521103
DOI: 10.1016/j.anpede.2025.504063

Genes

PTPN22
CD226
CTLA4
INS
FUT2
SH2B3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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