Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of TCR/CD3, PTPN22, CD28 and ZAP70 gene polymorphisms with type 1 diabetes risk in Tunisian population: family based association study.

Immunology letters - 1 Jan 2015

Ferjeni Zouidi, Bouzid D, Fourati H, Stayoussef M, Abida O, Kammoun T, Hachicha M, Penha-Gonçalves C, Masmoudi H

Abstract excerpt

Type 1 diabetes (T1D) is caused by an immune-mediated destruction of the insulin-producing β-cells. Several studies support the involvement of T cell activation molecules in the pathogenesis of T1D. In order to underline the role of the genes involved in this activation pathway, we investigated, using the Sequenom MassARRAY platform, 45 single-nucleotide polymorphisms (SNPs) belonging to TCR/CD3, CD28, ZAP70, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD28 Antigens
Share to CD3 Complex

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 1

Share to Lymphocyte Activation

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 22

Share to Receptors, Antigen, T-Cell, alpha-beta

Share to Tunisia

Share to ZAP-70 Protein-Tyrosine Kinase

Source

Identifiers

PMID: 25448703
DOI: 10.1016/j.imlet.2014.11.005

Genes

PTPN22
ZAP70
GAA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of TCR/CD3, PTPN22, CD28 and ZAP70 gene polymorphisms with type 1 diabetes risk in Tunisian population: family based association study.PMID 25448703Read ↗

Contribution of PTPN22, CD28, CTLA-4 and ZAP-70 variants to the risk of type 1 diabetes in TunisiansSemantic proximity Read ↗

CREM variant rs17583959 conferred susceptibility to T1D risk in the Tunisian families.Semantic proximity Read ↗

Association of single nucleotide polymorphisms in cytotoxic T-lymphocyte antigen 4 and susceptibility to autoimmune type 1 diabetes in Tunisians.Semantic proximity Read ↗

Association of TNF-α, CTLA4, and PTPN22 polymorphisms with type 1 diabetes and other autoimmune diseases in Brazil.Semantic proximity Read ↗

Genetic Epidemiology of Type 1 Diabetes in the 22 Arab Countries.Semantic proximity Read ↗

PTPN22 Single-Nucleotide Polymorphisms in Iranian Patients with Type 1 Diabetes Mellitus.Semantic proximity Read ↗

The association between PTPN22 C1858T gene polymorphism and type 1 diabetes mellitus: an Indonesian study.Semantic proximity Read ↗

The association of PTPN22 (rs2476601) and IL2RA (rs11594656) polymorphisms with T1D in Egyptian children.Semantic proximity Read ↗

Genetic susceptibility to type 2 diabetes: a global meta-analysis studying the genetic differences in Tunisian populations.Semantic proximity Read ↗

C1858T Polymorphism of Protein Tyrosine Phosphatase Non-receptor Type 22 (PTPN22): an eligible target for prevention of type 1 diabetes?Semantic proximity Read ↗

CD226 gene polymorphism (rs763361 C>T) is associated with susceptibility to type 1 diabetes mellitus among Egyptian children.Semantic proximity Read ↗

The associations between three genome-wide risk variants for serum C-peptide of T1D and autoantibody-positive T1D risk, and clinical characteristics in Chinese population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.