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Article

Susceptibility to type 1 diabetes conferred by the PTPN22 C1858T polymorphism in the Spanish population.

BMC medical genetics - 13 Aug 2007

Santiago Jose Luis, Martínez Alfonso, de la Calle Hermenegildo, Fernández-Arquero Miguel, Figueredo M Angeles, de la Concha Emilio G, Urcelay Elena

Abstract excerpt

BACKGROUND: The protein tyrosine phosphatase N22 gene (PTPN22) encodes a lymphoid-specific phosphatase (LYP) which is an important downregulator of T cell activation. A PTPN22 polymorphism, C1858T, was found associated with type 1 diabetes (T1D) in different Caucasian populations. In this study, we aimed at confirming the role of this variant in T1D predisposition in the Spanish population. METHODS: A...

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Source

Open in PubMed Open full text

Identifiers

PMID: 17697317
DOI: 10.1186/1471-2350-8-54
PMCID: PMC1976418

Genes

PTPN22

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Susceptibility to type 1 diabetes conferred by the PTPN22 C1858T polymorphism in the Spanish population.PMID 17697317Read ↗

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