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Article

Lipoxygenase pathways in Homo neanderthalensis: functional comparison with Homo sapiens isoforms.

Journal of lipid research - 1 May 2013

Chaitidis Pavlos, Adel Susan, Anton Monika, Heydeck Dagmar, Kuhn Hartmut, Horn Thomas

Abstract excerpt

Lipoxygenases (LOX) have been implicated in biosynthesis of pro- and anti-inflammatory mediators, and a previous report suggested compromised leukotriene signaling in H. neanderthalensis. To search for corresponding differences in leukotriene biosynthesis, we screened the Neandertal genome for LOX genes and found that, as modern humans, this archaic hominid contains six LOX genes (nALOX15, nALOX12, nALOX5,...

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Source

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Identifiers

PMID: 23475662
DOI: 10.1194/jlr.M035626
PMCID: PMC3622333

Genes

LOX
ALOX15
ALOX12
ALOX5
ALOXE3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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