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Article

Evolutionary alteration of ALOX15 specificity optimizes the biosynthesis of antiinflammatory and proresolving lipoxins.

Proceedings of the National Academy of Sciences of the United States of America - 26 Jul 2016

Adel Susan, Karst Felix, González-Lafont Àngels, Pekárová Mária, Saura Patricia, Masgrau Laura, Lluch José M, Stehling Sabine, Horn Thomas, Kuhn Hartmut, Heydeck Dagmar

Abstract excerpt

ALOX15 (12/15-lipoxygenase) orthologs have been implicated in maturational degradation of intracellular organelles and in the biosynthesis of antiinflammatory and proresolving eicosanoids. Here we hypothesized that lower mammals (mice, rats, pigs) express 12-lipoxygenating ALOX15 orthologs. In contrast, 15-lipoxygenating isoforms are found in higher primates (orangutans, men), and these results suggest an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27412860
DOI: 10.1073/pnas.1604029113
PMCID: PMC4968705

Genes

ALOX15

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Related research

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Evolutionary alteration of ALOX15 specificity optimizes the biosynthesis of antiinflammatory and proresolving lipoxins.PMID 27412860Read ↗

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12/15-Lipoxygenase orchestrates murine wound healing via PPARγ-activating oxylipins acting holistically to dampen inflammationSemantic proximity Read ↗

Functional polymorphism in ALOX15 results in increased allele-specific transcription in macrophages through binding of the transcription factor SPI1.Semantic proximity Read ↗

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