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Article

Evolutionary aspects of lipoxygenases and genetic diversity of human leukotriene signaling.

Progress in lipid research - 1 Jan 2015

Horn Thomas, Adel Susan, Schumann Ralf, Sur Saubashya, Kakularam Kumar Reddy, Polamarasetty Aparoy, Redanna Pallu, Kuhn Hartmut, Heydeck Dagmar

Abstract excerpt

Leukotrienes are pro-inflammatory lipid mediators, which are biosynthesized via the lipoxygenase pathway of the arachidonic acid cascade. Lipoxygenases form a family of lipid peroxidizing enzymes and human lipoxygenase isoforms have been implicated in the pathogenesis of inflammatory, hyperproliferative (cancer) and neurodegenerative diseases. Lipoxygenases are not restricted to humans but also occur in a large...

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Identifiers

PMID: 25435097
DOI: 10.1016/j.plipres.2014.11.001
PMCID: PMC7112624

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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