Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The biology of 5-lipoxygenase: function, structure, and regulatory mechanisms.

Proceedings of the Association of American Physicians - 1 Jan 2000

Silverman E S, Drazen J M

Abstract excerpt

5-Lipoxygenase (5-LO) catalyzes the two-step conversion of arachidonic acid to leukotriene A4 (LTA4). The first step consists of the oxidation of arachidonic acid to the unstable intermediate 5-hydroperoxyeicosatetraenoic acid (5-HPETE), and the second step is the dehydration of 5-HPETE to form LTA4. These events are the first committed reactions leading to the synthesis of all leukotrienes and play a critical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Allosteric Regulation
Share to Arachidonate 5-Lipoxygenase
Share to Arachidonic Acid

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Enzyme Induction

Share to Leukotrienes

Share to Organ Specificity

Source

Identifiers

PMID: 10591081
DOI: 10.1046/j.1525-1381.1999.t01-1-99231.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The biology of 5-lipoxygenase: function, structure, and regulatory mechanisms.PMID 10591081Read ↗

Evolutionary aspects of lipoxygenases and genetic diversity of human leukotriene signaling.Semantic proximity Read ↗

Genetic insights into 5-LOX-activating protein: a narrative review of disease associations.Semantic proximity Read ↗

The 5-lipoxygenase pathway in arterial wall biology and atherosclerosisSemantic proximity Read ↗

Functional Characterization of Knock-In Mice Expressing a 12/15-Lipoxygenating Alox5 Mutant Instead of the 5-Lipoxygenating Wild-Type Enzyme.Semantic proximity Read ↗

The biochemical, molecular, and genomic aspects of leukotriene C4 synthase.Semantic proximity Read ↗

The biological role of arachidonic acid 12-lipoxygenase (ALOX12) in various human diseases.Semantic proximity Read ↗

Soluble epoxide hydrolase: gene structure, expression and deletion.Semantic proximity Read ↗

Expanding expression of the 5-lipoxygenase pathway within the arterial wall during human atherogenesis.Semantic proximity Read ↗

The 5-lipoxygenase pathway: oxidative and inflammatory contributions to the Alzheimerâ€™s disease phenotypeSemantic proximity Read ↗

Mutations of Triad Determinants Changes the Substrate Alignment at the Catalytic Center of Human ALOX5.Semantic proximity Read ↗

Functional Characterization of Human Cysteinyl Leukotriene 1 Receptor Gene StructureSemantic proximity Read ↗

NOX5: from basic biology to signaling and disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.