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Article

The lipoxygenase gene ALOXE3 implicated in skin differentiation encodes a hydroperoxide isomerase.

Proceedings of the National Academy of Sciences of the United States of America - 5 Aug 2003

Yu Zheyong, Schneider Claus, Boeglin William E, Marnett Lawrence J, Brash Alan R

Abstract excerpt

Lipoxygenase (LOX) enzymes form fatty acid hydroperoxides used in membrane remodeling and cell signaling. Mammalian epidermal LOX type 3 (eLOX3) is distinctive in totally lacking this typical oxygenase activity. Surprisingly, genetic evidence has linked mutations in eLOX3 or a colocalizing enzyme, 12R-LOX, to disruption of the normal permeability barrier of the skin [Jobard, F., Lefèvre, C., Karaduman, A.,...

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Source

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Identifiers

PMID: 12881489
DOI: 10.1073/pnas.1633612100
PMCID: PMC170889

Genes

LOX
ALOXE3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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