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Article

Functional characterization of genetic enzyme variations in human lipoxygenases.

Redox biology - 1 Jan 2013

Horn Thomas, Reddy Kakularam Kumar, Anton Monika, Richter Constanze, Reddanna Pallu, Kuhn Hartmut

Abstract excerpt

Mammalian lipoxygenases play a role in normal cell development and differentiation but they have also been implicated in the pathogenesis of cardiovascular, hyperproliferative and neurodegenerative diseases. As lipid peroxidizing enzymes they are involved in the regulation of cellular redox homeostasis since they produce lipid hydroperoxides, which serve as an efficient source for free radicals. There are various...

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Source

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Identifiers

PMID: 24282679
DOI: 10.1016/j.redox.2013.11.001
PMCID: PMC3840004

Genes

ALOX12
ALOX15
ALOX5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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