Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional Characterization of Knock-In Mice Expressing a 12/15-Lipoxygenating Alox5 Mutant Instead of the 5-Lipoxygenating Wild-Type Enzyme.

Antioxidants & redox signaling - 1 Jan 2020

Marbach-Breitrück Eugenia, Kutzner Laura, Rothe Michael, Gurke Robert, Schreiber Yannick, Reddanna Pallu, Schebb Nils-Helge, Stehling Sabine, Wieler Lothar H, Heydeck Dagmar, Kuhn Hartmut

Abstract excerpt

Aims: Most mammalian genomes involve several genes encoding for functionally distinct arachidonate lipoxygenase (ALOX isoforms). Proinflammatory leukotrienes are formed via the ALOX5 pathway, but 12/15-lipoxygenating ALOX isoforms have been implicated in the biosynthesis of pro-resolving mediators. In vitro mutagenesis of the triad determinants abolished the leukotriene synthesizing activity of ALOX5, but the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alanine
Share to Arachidonate 5-Lipoxygenase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Asparagine

Share to Gene Knock-In Techniques

Share to Leukotrienes

Share to Linoleic Acid

Share to Phenylalanine

Share to PPAR gamma

Source

Identifiers

PMID: 31642348
DOI: 10.1089/ars.2019.7751

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional Characterization of Knock-In Mice Expressing a 12/15-Lipoxygenating Alox5 Mutant Instead of the 5-Lipoxygenating Wild-Type Enzyme.PMID 31642348Read ↗

Mutagenesis of triad determinants of rat Alox15 alters the specificity of fatty acid and phospholipid oxygenation.Semantic proximity Read ↗

Conversion of pro-inflammatory murine Alox5 into an anti-inflammatory 15S-lipoxygenating enzyme by multiple mutations of sequence determinants.Semantic proximity Read ↗

Mutations of Triad Determinants Changes the Substrate Alignment at the Catalytic Center of Human ALOX5.Semantic proximity Read ↗

12-Lipoxygenase inhibition improves glucose homeostasis and obesity-associated inflammation in human gene replacement miceSemantic proximity Read ↗

Evolutionary alteration of ALOX15 specificity optimizes the biosynthesis of antiinflammatory and proresolving lipoxins.Semantic proximity Read ↗

Leukotriene-deficient mice generated by targeted disruption of the 5-lipoxygenase gene.Semantic proximity Read ↗

The phenotype of a knockout mouse identifies flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic ageing.Semantic proximity Read ↗

The biology of 5-lipoxygenase: function, structure, and regulatory mechanisms.Semantic proximity Read ↗

Alterations of lipoxygenase specificity by targeted substrate modification and site-directed mutagenesis.Semantic proximity Read ↗

12/15-Lipoxygenase orchestrates murine wound healing via PPARγ-activating oxylipins acting holistically to dampen inflammationSemantic proximity Read ↗

12-Lipoxygenase inhibition delays onset of autoimmune diabetes in human gene replacement miceSemantic proximity Read ↗

Molecular basis for the catalytic inactivity of a naturally occurring near-null variant of human ALOX15.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.