Article
Strain typing of classical scrapie by transgenic mouse bioassay using protein misfolding cyclic amplification to replace primary passage.
PloS one - 1 Jan 2013
Beck Katy E, Thorne Leigh, Lockey Richard, Vickery Christopher M, Terry Linda A, Bujdoso Raymond, Spiropoulos John
Abstract excerpt
According to traditional murine bioassay methodology, prions must be serially passaged within a new host before a stable phenotype, and therefore a strain, can be assigned. Prions often transmit with difficulty from one species to another; a property termed the transmission barrier. Transgenic mouse lines that over express prion protein (PrP) genes of different species can circumvent the transmission barrier but...
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