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Propagation of ovine prions from "poor" transmitter scrapie isolates in ovine PrP transgenic mice.

Experimental and molecular pathology - 1 Feb 2012

Thackray Alana M, Hopkins Lee, Lockey Richard, Spiropoulos John, Bujdoso Raymond

Abstract excerpt

Ovine prion strains have typically been identified by their transmission properties, which include incubation time and lesion profile, in wild type mice. The existence of scrapie isolates that do not propagate in wild type mice, defined here as "poor" transmitters, are problematic for conventional prion strain typing studies as no incubation time or neuropathology can be recorded. This may arise because of the...

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Identifiers

PMID: 22120785
DOI: 10.1016/j.yexmp.2011.11.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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