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Article

Ovine PrP genotype is linked with lesion profile and immunohistochemistry patterns after primary transmission of classical scrapie to wild-type mice.

Journal of neuropathology and experimental neurology - 1 May 2010

Beck Katy E, Sallis Rosemary E, Lockey Richard, Simmons Marion M, Spiropoulos John

Abstract excerpt

It is currently believed that primary transmission of classical scrapie to wild-type mice is inefficient and characterized by low attack rates and variable incubation periods and lesion profiles. Consequently, strain characterization of classical scrapie in these mice relies on subpassage. The aim of this study was to perform a retrospective analysis of lesion profiles and immunohistochemistry patterns after...

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PMID: 20418778
DOI: 10.1097/NEN.0b013e3181db2497

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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