Article
Human CCR6+ Th Cells Show Both an Extended Stable Gradient of Th17 Activity and Imprinted Plasticity.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 2023
Singh Satya P, Parween Farhat, Edara Nithin, Zhang Hongwei H, Chen Jinguo, Otaizo-Carrasquero Francisco, Cheng Debby, Oppenheim Nicole A, Ransier Amy, Zhu Wenjun, Shamsaddini Amirhossein, Gardina Paul J, Darko Samuel W, Singh Tej Pratap, Douek Daniel C, Myers Timothy G, Farber Joshua M
Abstract excerpt
Th17 cells have been investigated in mice primarily for their contributions to autoimmune diseases. However, the pathways of differentiation of Th17 and related Th cells (type 17 cells) and the structure of the type 17 memory population in humans are not well understood; such understanding is critical for manipulating these cells in vivo. By exploiting differences in levels of surface CCR6, we found that human...
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