Article
The IL23R A/Gln381 allele promotes IL-23 unresponsiveness in human memory T-helper 17 cells and impairs Th17 responses in psoriasis patients.
The Journal of investigative dermatology - 1 Oct 2013
Di Meglio Paola, Villanova Federica, Napolitano Luca, Tosi Isabella, Terranova Barberio Manuela, Mak Rose K, Nutland Sarah, Smith Catherine H, Barker Jonathan N W N, Todd John A, Nestle Frank O
Abstract excerpt
We and others have shown that the minor, nonconserved allele Gln381 of the Arg381Gln single-nucleotide polymorphism (rs11209026G>A) of the IL-23 receptor gene (IL23R) protects against psoriasis. Moreover, we have recently shown impaired IL-23-induced IL-17A production and STAT-3 phosphorylation i...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.