Autoimmune Memory T Helper 17 Cell Function and Expansion Are Dependent on Interleukin-23

Abstract excerpt

Interleukin-23 (IL-23) is essential for the differentiation of pathogenic effector T helper 17 (Th17) cells, but its role in memory Th17 cell responses is unclear. Using the experimental autoimmune encephalomyelitis (EAE) model, we report that memory Th17 cells rapidly expanded in response to rechallenge and migrated to the CNS in high numbers, resulting in earlier onset and increased severity of clinical...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Psoriasis: Treatment and Pathogenesis
• Share to T-cell and B-cell Immunology
• Share to Whipple's Disease and Interleukins