Article
Demethylation of the RORC2 and IL17A in human CD4+ T lymphocytes defines Th17 origin of nonclassic Th1 cells.
Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2015
Mazzoni Alessio, Santarlasci Veronica, Maggi Laura, Capone Manuela, Rossi Maria Caterina, Querci Valentina, De Palma Raffaele, Chang Hyun-Dong, Thiel Andreas, Cimaz Rolando, Liotta Francesco, Cosmi Lorenzo, Maggi Enrico, Radbruch Andreas, Romagnani Sergio, Dong Jun, Annunziato Francesco
Abstract excerpt
Th17-derived Th1 lymphocytes, termed nonclassic, differ from classic Th1 cells because of the presence of retinoic acid orphan receptor (ROR)C2 and the surface expression of CD161 and CCR6. We demonstrate in this article that nonclassic Th1 cells, like Th17 cells, have a marked RORC2 and IL17A demethylation, whereas classic Th1 cells exhibit a complete methylation of these genes. The analysis of RORC2 DNA...
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