Article
Fine-mapping angiotensin-converting enzyme gene: separate QTLs identified for hypertension and for ACE activity.
PloS one - 1 Jan 2013
Chung Chia-Min, Wang Ruey-Yun, Fann Cathy S J, Chen Jaw-Wen, Jong Yuh-Shiun, Jou Yuh-Shan, Yang Hsin-Chou, Kang Chih-Sen, Chen Chien-Chung, Chang Huan-Cheng, Pan Wen-Harn
Abstract excerpt
Angiotensin-converting enzyme (ACE) has been implicated in multiple biological system, particularly cardiovascular diseases. However, findings associating ACE insertion/deletion polymorphism with hypertension or other related traits are inconsistent. Therefore, in a two-stage approach, we aimed to fine-map ACE in order to narrow-down the function-specific locations. We genotyped 31 single nucleotide polymorphisms...
Topics
- Adult
- Age of Onset
- Exons
- Female
- Haplotypes
- Humans
- Hypertension
- Introns
- Linkage Disequilibrium
- Male
- Middle Aged
- Pedigree
- Peptidyl-Dipeptidase A
- Phenotype