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Allele Frequency of ACE2 Intron Variants and Its Association with Blood Pressure.

DNA and cell biology - 1 Nov 2020

Lozano-Gonzalez Karla, Padilla-Rodríguez Elba, Texis Tomas, Gutiérrez Marco N, Rodríguez-Dorantes Mauricio, Cuevas-Córdoba Betzaida, Ramírez-García Eliseo, Mino-León Dolores, Sánchez-García Sergio, Gonzalez-Covarrubias Vanessa

Abstract excerpt

Angiotensin-converting enzyme 2 (ACE2) is known as the counter-regulator of the renin-angiotensin system, it cleaves angiotensin II to render Ag 1-7, a potent vasodilator with multiple roles in cardiovascular protection. A few studies have pinpointed ACE2 polymorphisms and their relationship with heart function and hypertension in a sex-dependent manner. These observations still lack replication mostly for...

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Identifiers

PMID: 33016778
DOI: 10.1089/dna.2020.5804

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