Article
High-resolution mapping for essential hypertension using microsatellite markers.
Hypertension (Dallas, Tex. : 1979) - 1 Mar 2007
Yatsu Keisuke, Mizuki Nobuhisa, Hirawa Nobuhito, Oka Akira, Itoh Norihiko, Yamane Takahiro, Ogawa Momoko, Shiwa Tadashi, Tabara Yasuharu, Ohno Shigeaki, Soma Masayoshi, Hata Akira, Nakao Kazuwa, Ueshima Hirotsugu, Ogihara Toshio, Tomoike Hitonobu, Miki Tetsuro, Kimura Akinori, Mano Shuhei, Kulski Jerzy K, Umemura Satoshi, Inoko Hidetoshi
Abstract excerpt
During the past decade, considerable efforts and resources have been devoted to elucidating the multiple genetic and environmental determinants responsible for hypertension and its associated cardiovascular diseases. The success of positional cloning, fine mapping, and linkage analysis based on whole-genome screening, however, has been limited in identifying multiple genetic determinants affecting diseases,...
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