Genome-wide scan for quantitative ACE activity in Taiwan young-onset hypertension study.

doi:10.1159/000108940

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Article

Genome-wide scan for quantitative ACE activity in Taiwan young-onset hypertension study.

Human heredity - 1 Jan 2008

Wang Ruey-Yun, Chung Chia-Min, Fann Cathy S J, Yang Hsin-Chou, Chen Jaw-Wen, Jong Yuh-Shiun, Jou Yuh-Shan, Lo Huey-Ming, Ho Feng-Ming, Kang Chih-Sen, Chen Chien-Chung, Chang Huan-Cheng, Shyue Song-Kun, Pan Wen-Harn

Abstract excerpt

OBJECTIVES: Angiotensin converting enzyme (ACE) plays major roles in the pathogenesis of cardiovascular diseases (CVD). However, findings on the relations between ACE variants and CVD have not been consistent. The purpose of this study was to map quantitative trait loci (QTL) for serum ACE activity, a heritable endophenotype of cardiovascular diseases (estimated heritability = 0.58). METHODS: With 1,271...

Topics

Age of Onset
Cardiovascular Diseases
Female
Genome, Human
Genotype
Humans
Hypertension
Linkage Disequilibrium
Male
Pedigree
Peptidyl-Dipeptidase A
Phenotype
Taiwan

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PMID: 17898539
DOI: 10.1159/000108940

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