Article
Effects of SORL1 gene on Alzheimer's disease. Focus on gender, neuropsychiatric symptoms and pro-inflammatory cytokines.
Current Alzheimer research - 1 Feb 2013
Olgiati Paolo, Politis Antonis, Albani Diego, Rodilossi Serena, Polito Letizia, Zisaki Aikaterini, Piperi Christina, Liappas Ioannis, Stamouli Evangelia, Mailis Antonis, Batelli Sara, Forloni Gianluigi, Marsano Agnese, Balestri Martina, Soldatos Costantine R, De Ronchi Diana, Kalofoutis Anastasios, Serretti Alessandro
Abstract excerpt
It was suggested that the gene encoding for sorLa, (SORL1) may affect Alzheimer's disease (LOAD) through a female-specific mechanism. The aims of this study were to confirm the role of gender in modulating the association between SORL1 and LOAD and to ascertain the influence of SORL1 on cognitive impairment, neuropsychiatric symptoms (BPSD) and secretion of pro-inflammatory cytokines. Ninety six outpatients with...
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