Association of SORL1 alleles with late-onset Alzheimer's disease. findings from the GIGAS_LOAD study and mega-analysis.

doi:10.2174/156720512800492431

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Association of SORL1 alleles with late-onset Alzheimer's disease. findings from the GIGAS_LOAD study and mega-analysis.

Current Alzheimer research - 1 May 2012

Olgiati Paolo, Politis Antonis, Albani Diego, Rodilossi Serena, Polito Letizia, Ateri Eleonora, Zisaki Aikaterini, Piperi Christina, Liappas Ioannis, Stamouli Evangelia, Mailis Antonis, Atti Anna R, Ferrari Barbara, Morini Valentina, Moretti Francesca, Biella Gloria, Forloni Gianluigi, Papadimitriou George N, Ronchi Diana De, Kalofoutis Anastasios, Serretti Alessandro

Abstract excerpt

The pathophysiology of Alzheimer's disease (AD) is influenced by sorting-protein related receptor (sorLa) that is less expressed in AD patients. The gene encoding sorLa (SORL1) has been investigated as a susceptibility factor for late-onset AD (LOAD) with conflicting results. Our objectives were to confirm the association between SORL1 SNPs and LOAD in two independent South-European centers and to perform a...

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PMID: 22044026
DOI: 10.2174/156720512800492431

Genes

SORL1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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