Article
Amyloid-β-related genes SORL1 and ACE are genetically associated with risk for late-onset Alzheimer disease in the Chinese population.
Alzheimer disease and associated disorders - 1 Jan 2000
Ning Mei, Yang Yifeng, Zhang Zhou, Chen Zhuo, Zhao Teng, Zhang Di, Zhou Daizhan, Xu Jie, Liu Zhe, Wang Yabing, Liu Yun, Zhao Xinzhi, Li Weidong, Li Sheng, He Lin
Abstract excerpt
Late-onset Alzheimer Disease (LOAD) is a common neurodegenerative disease, and one of its major pathologic characteristics is senile plaques. Proteins encoded by SORL1 and ACE have been shown to be related to the processing, trafficking, and degradation of Amyloid-β, the principal component of senile plaques. In this paper, we investigated whether SORL1 and ACE are associated with LOAD. We recruited 144 LOAD...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.