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Article

UHRF1 targets DNMT1 for DNA methylation through cooperative binding of hemi-methylated DNA and methylated H3K9.

Nature communications - 1 Jan 2013

Liu Xiaoli, Gao Qinqin, Li Pishun, Zhao Qian, Zhang Jiqin, Li Jiwen, Koseki Haruhiko, Wong Jiemin

Abstract excerpt

Epigenetic inheritance of DNA methylation in mammals requires a multifunctional protein UHRF1, which is believed to recruit DNMT1 to DNA replication forks through a unique hemi-methylated CpG-binding activity. Here we demonstrate that the UHRF1 mutants deficient in binding either hemi-methylated CpG or H3K9me2/3, but not both, are able to associate with pericentric heterochromatin, recruit Dnmt1 and partially...

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Share to DNA (Cytosine-5-)-Methyltransferase 1

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Source

Identifiers

PMID: 23463006
DOI: 10.1038/ncomms2562

Genes

UHRF1
DNMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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