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Article

Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation.

Molecular cell - 17 Aug 2017

Ferry Laure, Fournier Alexandra, Tsusaka Takeshi, Adelmant Guillaume, Shimazu Tadahiro, Matano Shohei, Kirsh Olivier, Amouroux Rachel, Dohmae Naoshi, Suzuki Takehiro, Filion Guillaume J, Deng Wen, de Dieuleveult Maud, Fritsch Lauriane, Kudithipudi Srikanth, Jeltsch Albert, Leonhardt Heinrich, Hajkova Petra, Marto Jarrod A, Arita Kyohei, Shinkai Yoichi, Defossez Pierre-Antoine

Abstract excerpt

DNA methylation is an essential epigenetic mark in mammals that has to be re-established after each round of DNA replication. The protein UHRF1 is essential for this process; it has been proposed that the protein targets newly replicated DNA by cooperatively binding hemi-methylated DNA and H3K9me2/3, but this model leaves a number of questions unanswered. Here, we present evidence for a direct recruitment of...

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Identifiers

PMID: 28803780
DOI: 10.1016/j.molcel.2017.07.012

Genes

UHRF1
LIG1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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