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Article

Functional characterization of UHRF1 variants in facilitating DNA methylation.

The Journal of biological chemistry - 1 Jul 2026

Liu Bigang, Nayvelt Kaila, Hardikar Swanand, Kondo Kimie, Estecio Marcos R, Cheng Xiaodong, Chen Taiping

Abstract excerpt

Ubiquitin-like with plant homeodomain (PHD) and really interesting new gene (RING) finger domains 1 (UHRF1) is essential for DNA methylation inheritance. However, the functional impacts of several natural and engineered UHRF1 variants are either insufficiently characterized or obscured by conflicting results, with some discrepancies likely stemming from cellular toxicity and adaptive responses induced by DNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42140430
DOI: 10.1016/j.jbc.2026.113149
PMCID: PMC13264223

Genes

UHRF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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