Article

UHRF1-SRA recognizes symmetric non-CG methylated DNA through dual-flip out of 5-methyl cytosines

2019-12-19

Abstract excerpt

Non-CG DNA methylation (non-mCG) is enriched in the genome of brain neurons and germline cells. Non-mCG is differentially distributed on neuronal X-chromosome in males and females. Accumulation of non-mCG during postnatal brain development correlates with reduced gene expression and inactivation of distal regulatory elements, and allele specific gene regulation. Recently, UHRF1 has been found to contribute to de...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4585d55d-92fb-5991-9d7d-cc5524a0986f
DOI: 10.1101/2019.12.17.880419

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

UHRF1-SRA recognizes symmetric non-CG methylated DNA through dual-flip out of 5-methyl cytosinesDOI 10.1101/2019.12.17.880419Read

Non-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cellsSemantic proximity Read

UHRF1 targets DNMT1 for DNA methylation through cooperative binding of hemi-methylated DNA and methylated H3K9.Semantic proximity Read

Functional characterization of UHRF1 variants in facilitating DNA methylation.Semantic proximity Read

Non-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cellsSemantic proximity Read

A dual flip-out mechanism for 5mC recognition by the Arabidopsis SUVH5 SRA domain and its impact on DNA methylation and H3K9 dimethylation in vivo.Semantic proximity Read

DNMT1 mutations found in HSANIE patients affect interaction with UHRF1 and neuronal differentiation.Semantic proximity Read

DNA Hypermethylation and Unstable Repeat Diseases: A Paradigm of Transcriptional Silencing to Decipher the Basis of Pathogenic MechanismsSemantic proximity Read

Neuronal non-CG methylation is an essential target for MeCP2 functionSemantic proximity Read

Novel compound heterozygous mutations in UHRF1 are associated with atypical immunodeficiency, centromeric instability and facial anomalies syndrome with distinctive genome-wide DNA hypomethylation.Semantic proximity Read

DNA methylation governs the sensitivity of repeats to restriction by the HUSH-MORC2 corepressorSemantic proximity Read

Refined read-out: The hUHRF1 Tandem-Tudor domain prefers binding to histone H3 tails containing K4me1 in the context of H3K9me2/3Semantic proximity Read

Domains of methylated CAC and CG target MeCP2 to tune transcription in the brainSemantic proximity Read