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Article

DNMT3B PWWP mutations cause hypermethylation of heterochromatin.

EMBO reports - 1 Mar 2024

Taglini Francesca, Kafetzopoulos Ioannis, Rolls Willow, Musialik Kamila Irena, Lee Heng Yang, Zhang Yujie, Marenda Mattia, Kerr Lyndsay, Finan Hannah, Rubio-Ramon Cristina, Gautier Philippe, Wapenaar Hannah, Kumar Dhananjay, Davidson-Smith Hazel, Wills Jimi, Murphy Laura C, Wheeler Ann, Wilson Marcus D, Sproul Duncan

Abstract excerpt

The correct establishment of DNA methylation patterns is vital for mammalian development and is achieved by the de novo DNA methyltransferases DNMT3A and DNMT3B. DNMT3B localises to H3K36me3 at actively transcribing gene bodies via its PWWP domain. It also functions at heterochromatin through an unknown recruitment mechanism. Here, we find that knockout of DNMT3B causes loss of methylation predominantly at...

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Share to DNA (Cytosine-5-)-Methyltransferases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methyltransferase 3A

Share to Heterochromatin

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Source

Open in PubMed Open full text

Identifiers

PMID: 38291337
DOI: 10.1038/s44319-024-00061-5
PMCID: PMC7615734

Genes

DNMT3B
DNMT3A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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