Article

Non-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cells

2023-07-11

Abstract excerpt

DNA methylation is an essential epigenetic chromatin modification, and its maintenance in mammals requires the protein UHRF1. It is yet unclear if UHRF1 functions solely by stimulating DNA methylation maintenance by DNMT1, or if it has important additional functions. Using degron alleles, we show that UHRF1 depletion causes a much greater loss of DNA methylation than DNMT1 depletion. This is not caused by passive...

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Literature Corpus work: 5ba652aa-2816-5f21-bc00-83e1f505c2f2
DOI: 10.1101/2023.07.11.548318

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