Article
Defining UHRF1 Domains that Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic Properties.
Cancer cell - 15 Apr 2019
Kong Xiangqian, Chen Jie, Xie Wenbing, Brown Stephen M, Cai Yi, Wu Kaichun, Fan Daiming, Nie Yongzhan, Yegnasubramanian Srinivasan, Tiedemann Rochelle L, Tao Yong, Chiu Yen Ray-Whay, Topper Michael J, Zahnow Cynthia A, Easwaran Hariharan, Rothbart Scott B, Xia Limin, Baylin Stephen B
Abstract excerpt
UHRF1 facilitates the establishment and maintenance of DNA methylation patterns in mammalian cells. The establishment domains are defined, including E3 ligase function, but the maintenance domains are poorly characterized. Here, we demonstrate that UHRF1 histone- and hemimethylated DNA binding functions, but not E3 ligase activity, maintain cancer-specific DNA methylation in human colorectal cancer (CRC) cells....
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