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Role of UHRF1 in de novo DNA methylation in oocytes and maintenance methylation in preimplantation embryos

4 Oct 2017

Abstract excerpt

The methylation of cytosine at CG sites in the mammalian genome is dynamically reprogrammed during gametogenesis and preimplantation development. It was previously shown that oocyte-derived DNMT1 (a maintenance methyltransferase) is essential for maintaining and propagating CG methylation at imprinting control regions in preimplantation embryos. In mammalian somatic cells, hemimethylated-CG-binding protein UHRF1...

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PMID: 28976982
DOI: 10.1371/journal.pgen.1007042

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