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Article

Carcinoma‐associated fibroblasts: Non‐neoplastic tumour‐promoting mesenchymal cells

4 Mar 2013

Abstract excerpt

Cancerous stroma coevolves alongside tumour progression, thereby promoting the malignant conversion of epithelial carcinoma cells. To date, an abundance of data have supported crucial roles of the tumour microenvironment (TME) in providing cancer cells with proliferative, migratory, survival and invasive propensities favouring the processes of tumourigenesis. The cancerous reactive stroma is frequently populated...

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PMID: 23460038
DOI: 10.1002/jcp.24347

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