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Article

The Drosophila ortholog of MLL3 and MLL4, trithorax related, functions as a negative regulator of tissue growth.

Molecular and cellular biology - 1 May 2013

Kanda Hiroshi, Nguyen Alexander, Chen Leslie, Okano Hideyuki, Hariharan Iswar K

Abstract excerpt

The human MLL genes (MLL1 to MLL4) and their Drosophila orthologs, trithorax (trx) and trithorax related (trr), encode proteins capable of methylating histone H3 on lysine 4. MLL1 and MLL2 are most similar to trx, while MLL3 and MLL4 are more closely related to trr. Several MLL genes are mutated...

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Share to Chromosomal Proteins, Non-Histone
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23459941
DOI: 10.1128/MCB.01585-12
PMCID: PMC3624179

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23459941-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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