Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A SET-domain-independent role of WRAD complex in cell-cycle regulatory function of mixed lineage leukemia.

Nucleic acids research - 1 Jul 2014

Ali Aamir, Veeranki Sailaja Naga, Tyagi Shweta

Abstract excerpt

MLL, the trithorax ortholog, is a well-characterized histone 3 lysine 4 methyltransferase that is crucial for proper regulation of the Hox genes during embryonic development. Chromosomal translocations, disrupting the Mll gene, lead to aggressive leukemia with poor prognosis. However, the functions of MLL in cellular processes like cell-cycle regulation are not well studied. Here we show that the MLL has a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle
Share to Cell Cycle Checkpoints
Share to G1 Phase Cell Cycle Checkpoints

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone-Lysine N-Methyltransferase

Share to MCF-7 Cells

Share to Myeloid-Lymphoid Leukemia Protein

Share to Protein Subunits

Share to S Phase

Source

Open in PubMed Open full text

Identifiers

PMID: 24880690
DOI: 10.1093/nar/gku458
PMCID: PMC4081079

Genes

SET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A SET-domain-independent role of WRAD complex in cell-cycle regulatory function of mixed lineage leukemia.PMID 24880690Read ↗

An MLL-dependent network sustains hematopoiesisSemantic proximity Read ↗

Mechanisms of Transformation by MLLSemantic proximity Read ↗

MLL: how complex does it get?Semantic proximity Read ↗

Molecular and Epigenetic Mechanisms of MLL in Human LeukemogenesisSemantic proximity Read ↗

MLL histone methylases in gene expression, hormone signaling and cell cycleSemantic proximity Read ↗

THE CRITICAL ROLE OF CHROMOSOME TRANSLOCATIONS IN HUMAN LEUKEMIASSemantic proximity Read ↗

Impaired function of primitive hematopoietic cells in mice lacking the Mixed-Lineage-Leukemia homolog MLL5.Semantic proximity Read ↗

The stem cell factor SALL4 is an essential transcriptional regulator in mixed lineage leukemia-rearranged leukemogenesisSemantic proximity Read ↗

The molecular biology of mixed lineage leukemiaSemantic proximity Read ↗

Effects of Mixed Lineage Leukaemia, the human homologue of Trithorax, and its leukaemic fusion proteins in Drosophila melanogasterSemantic proximity Read ↗

A MENage à Trois in leukemia.Semantic proximity Read ↗

Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.