Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cancer-derived UTX TPR mutations G137V and D336G impair interaction with MLL3/4 complexes and affect UTX subcellular localization.

Oncogene - 1 Apr 2020

Kato Hiroyuki, Asamitsu Kaori, Sun Wendi, Kitajima Shojiro, Yoshizawa-Sugata Naoko, Okamoto Takashi, Masai Hisao, Poellinger Lorenz

Abstract excerpt

The ubiquitously transcribed tetratricopeptide repeat on X chromosome (UTX) is a major histone H3 lysine 27 (H3K27) demethylase and the mixed-lineage leukemia (MLL) proteins are the H3K4 methyltransferases. UTX is one of the major components of MLL3- and MLL4-containing (MlLL3/4) complexes and likely has functions within the complexes. Although UTX is frequently mutated in various types of cancer and is thought...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Cell Cycle Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colorectal Neoplasms

Share to CRISPR-Cas Systems

Share to HCT116 Cells

Share to Histone Demethylases

Share to Histone-Lysine N-Methyltransferase

Share to Jumonji Domain-Containing Histone Demethylases

Source

Identifiers

PMID: 32071397
DOI: 10.1038/s41388-020-1218-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cancer-derived UTX TPR mutations G137V and D336G impair interaction with MLL3/4 complexes and affect UTX subcellular localization.PMID 32071397Read ↗

Utx loss causes myeloid transformation.Semantic proximity Read ↗

MLL5 (KMT2E): structure, function, and clinical relevance.Semantic proximity Read ↗

Targeting human SET1/MLL family of proteinsSemantic proximity Read ↗

Role of somatic cancer mutations in human protein lysine methyltransferases.Semantic proximity Read ↗

Probing the Cancer Mutational Landscape of KMT2 Regulatory Subunits.Semantic proximity Read ↗

A mutant ASXL1-EHMT complex contributes to heterochromatin dysfunction in clonal hematopoiesis and chronic monomyelocytic leukemiaSemantic proximity Read ↗

A mutant ASXL1-BAP1-EHMT complex contributes to heterochromatin dysfunction in clonal hematopoiesis and chronic monomyelocytic leukemia.Semantic proximity Read ↗

Human ASXL1-Mutant Hematopoiesis Is Driven by a Truncated Protein Associated with Aberrant Deubiquitination of H2AK119.Semantic proximity Read ↗

Somatic mutations of MLL4/COMPASS induce cytoplasmic localization providing molecular insight into cancer prognosis and treatment.Semantic proximity Read ↗

The tumor-maintaining function of UTX/KDM6A in DNA replication and the PARP1-dependent repair pathwaySemantic proximity Read ↗

Histone H3 lysine 4 methyltransferase KMT2D.Semantic proximity Read ↗

Acute myeloid leukemias with <i>UBTF</i> tandem duplications are sensitive to menin inhibitorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.