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Article

Precise genetic mapping and integrative bioinformatics in Diversity Outbred mice reveals Hydin as a novel pain gene.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jun 2014

Recla Jill M, Robledo Raymond F, Gatti Daniel M, Bult Carol J, Churchill Gary A, Chesler Elissa J

Abstract excerpt

Mouse genetics is a powerful approach for discovering genes and other genome features influencing human pain sensitivity. Genetic mapping studies have historically been limited by low mapping resolution of conventional mouse crosses, resulting in pain-related quantitative trait loci (QTL) spanning several megabases and containing hundreds of candidate genes. The recently developed Diversity Outbred (DO)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24700285
DOI: 10.1007/s00335-014-9508-0
PMCID: PMC4032469

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